A Plasmart Initiative
Sequence Me
White-glove whole-genome sequencing and archival for families affected by hereditary blood factor deficiencies.
A · T · G · C → I · II · V · VII · VIII · IX · X · XI · XII · XIII
White-glove whole-genome sequencing and archival for families affected by hereditary blood factor deficiencies.
Map every clotting factor. Own the data that could change everything. Sequence Me provides 30× whole-genome sequencing through our Sequencing.com partnership — complete FASTQ, BAM, and VCF delivery for every family member.
Bleeding disorders are often overlooked and underdiagnosed. Despite being the most common inherited bleeding conditions, coagulation factor deficiencies receive far less research focus than conditions of similar prevalence. Many families remain undiagnosed or improperly treated for generations.
Current treatments have significant limitations. Many patients rely on frequent IV infusions of clotting factor concentrates. Women with bleeding disorders face heavy menstrual bleeding and dangerous postpartum hemorrhage. A single nucleotide change in any of the thirteen coagulation factor genes can mean a lifetime of medical intervention.
A complex network of proteins working in harmony. A single nucleotide change in any factor can cause a bleeding disorder.
The coagulation cascade: intrinsic and extrinsic pathways converging on fibrin clot formation.
Hereditary deficiencies in any of the thirteen coagulation factors cause bleeding disorders. 30× whole-genome sequencing covers them all.
| Gene | Condition | 30× WGS | Genotyping |
|---|---|---|---|
| F8 | Hemophilia A | 186,561 | 3 |
| F9 | Hemophilia B | 33,784 | 0 |
| VWF | von Willebrand Disease | 179,426 | 6 |
| F5 | Factor V Deficiency | 71,122 | 1 |
| F7 | Factor VII Deficiency | 31,330 | 0 |
| F11 | Factor XI Deficiency | 55,188 | 0 |
| F13A1 | Factor XIII Deficiency | 66,994 | 0 |
Variant counts per gene. Genotyping checks markers; sequencing reads the entire gene. Data from Sequencing.com.
By analyzing parental and child DNA, we seek to pioneer precise interventions that correct underlying mutations at their source — so children, grandchildren, and generations to come can live free from the burden of bleeding disorders.
Based on Sequencing.com's Healthcare Pro report format — the same structure used for clinical-grade genetic findings.
Illustrative example. Actual reports are generated by Sequencing.com's Healthcare Pro app.
We handle every step. You provide the saliva.
Submit family information. Privacy-first naming.
We order 30× WGS kits from Sequencing.com.
Saliva or cheek swab at home. Return prepaid.
30× whole-genome sequencing. 6–10 weeks.
Organized, checksummed, encrypted media.
Every file organized, checksummed, and delivered on encrypted media.
Already have whole-genome data? Bring-your-own-data archival starts at $50.
Every genome sequenced today is a family prepared for tomorrow's cures.
Order Through Sequencing.com